Abstract
A study was made of the effect produced by the folic and nicotinic acids deficiency caused by the administration of aminopterin and β-acetylpyridine on the external secretory activity of the pancreas. Experiments were carried out on 6 dogs with a chronic fistula of the pancreatic duct after I. P. Pavlov. Aminopterine was administered parenterally in daily doses of 0.5–2.0 mg. The number of injections in dogs differed from 9 to 34 for 33–63 days. During antimetabolite administration there was a reduction of secretion in response to food stimuli for a period of 5 h; the course of secretion according to hourly intervals, characteristic of different food stimuli, has also changed. There were no changes in the concentration of amylase, lipase, and trypsin in the juice.
Published Version
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