EFFECT OF A COMBINATION OF POLYMORPHIC VARIANTS OF THE PPARG2 (PRO12ALA), ADRB2 (GLN27GLU), ADRB2 (AGR16GLY), ADRB3 (TRP64AGR), AND FABP2 (THR54ALA) GENES AND THE RISK OF ARTERIAL

Abstract

Objective: To establish the relationship between different combinations of polymorphic variants of PPARG2 (Pro12Ala), ADRB2 (Gln27Glu), ADRB2 (Agr16Gly), ADRB3 (Trp64Agr), and FABP2 (Thr54Ala) genes and hypertension Design and method: 191 adults (33.1% of men and 66.9% of women), mean age (52.7 ± 10.8) years with hypertension were examined. Blood pressure was measured according to the guidelines for the management of patients with hypertension of the European Society of Cardiology (2018). Conducted daily monitoring of blood pressure. Determination of polymorphisms in the genes PPARG2 (Pro12Ala), ADRB2 (Gln27Glu), ADRB2 (Agr16Gly), ADRB3 (Trp64Agr), and FABP2 (Thr54Ala) of the PPARG2 (Pro12Ala) receptor by the method of real-time polymerase chain reaction polymerase chain reaction. Statistical processing of the obtained data was performed using the statistical package SPSS 17 (IBM) Results: In the study population, target blood pressure reduction was observed in 63% of patients after 12 months of follow-up. Patients with controlled arterial hypertension (60.7%) predominated in the group of those who reached the target blood pressure values, while patients with overt hypertension (42.9%) predominated in the group with those who did not reach the target blood pressure values. Patients were divided into groups depending on the phenotype of hypertension. The odds ratio for hypertension was found to be 1.11 for PPARG2 (CC vs CG+GG); 1.32 for ADRB2 (CG vs CC+CG); 1.05 for ADRB2 (AG vs. AA+AG); 2.0 for ADRB3 (TT vs. CC) and 1.33 for FABP2 (GG vs. AG+AA) (95% confidence interval). The odds ratio of the combination of the polymorphic CC variant of the ADRB3 gene (Trp64Agr) and the AA variant of the ADRB2 gene (Agr16Gly) in groups with overt AH was 2.33. Other combinations of genes and their polymorphic variants did not provide a reliable diagnostic criterion for the relationship with arterial hypertension phenotypes Conclusions: The combination of the CC variant of the ADRB3 gene (Trp64Agr) and the AA variant of the ADRB2 gene (Agr16Gly) is a reliable marker of overt arterial hypertension