Effect of a 12-week high-intensity exercise intervention: a comparison of cardiac exercise adaptations during biological disease-modifying antirheumatic drug treatment (TNF inhibitors vs IL-6 signalling inhibitors) in patients with rheumatoid arthritis – study protocol for a randomised controlled trial

Simon Jønck,Iben Elmerdahl Rasmussen,Lars Køber,Regitse Højgaard Christensen,Pil Højgaard,Ronan M G Berg,Lene Dreyer,Niels Vejlstrup,Bente Klarlund Pedersen,Helga Ellingsgaard,Søren Jacobsen,Malte Lund Adamsen,Morten Asp Vonsild Lund,Peter Godsk Jørgensen

doi:10.1136/bmjopen-2022-068600

Effect of a 12-week high-intensity exercise intervention: a comparison of cardiac exercise adaptations during biological disease-modifying antirheumatic drug treatment (TNF inhibitors vs IL-6 signalling inhibitors) in patients with rheumatoid arthritis – study protocol for a randomised controlled trial

Simon Jønck, Iben Elmerdahl Rasmussen + Show 12 more

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https://doi.org/10.1136/bmjopen-2022-068600

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Journal: BMJ Open	Publication Date: May 1, 2023
Citations: 1	License type: open-access

Affiliation: Copenhagen University Hospital, Rigshospitalet, Holbæk Sygehus, University of Copenhagen, Aalborg University Hospital, Herlev Hospital

#Cardiac Adaptations #Tumour Necrosis Factor Inhibitors #Biological Disease-modifying Antirheumatic Drug Treatment #Min High-intensity Interval Training #Change In Left Ventricular Mass #State In Rheumatoid Arthritis #High-intensity Interval Training Sessions #Rheumatoid Arthritis #Danish Medicines Agency #High-intensity Interval Training

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IntroductionThe chronic inflammatory state in rheumatoid arthritis (RA) augments the risk of cardiovascular disease (CVD), with pro-inflammatory cytokines tumour necrosis factor (TNF) and interleukin 6 (IL-6) playing a vital role....

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