Abstract
2, 4-Dinitrophenol (DNP), which caused rapid protein thiol (PSH) loss in tissue of muscle and intestine, resulted in decreased drug transport from muscle tissue and from intestinal connective tissue into the blood circulation. The effect of DNP in decreasing the transport of cefmetazole was greater than that in decreasing the transport of diclofenac, suggesting that PSH loss in the tissue may decrease the apparent diffusion of solute in the tissue fluid through the aqueous pathway. Trifluoperazine inhibited the rapid PSH loss caused by DNP with a recovery of drug transport; this also supports the view that PSH loss may be involved in the mechanism of decrease in the diffusion of solute by DNP.
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