Abstract
n this project we studied the effect of 2-nitropropane in spontaneous and evoked chemical neurotransmission, using as a model the frog neuromuscular junction, in vitro. The experiments were carried out in the sciatic nerve- sartorius muscle preparation. Our results show that neurotransmission was inhibited, manifesting as a decrease in the amplitude and instantaneous frequency of miniature end-plate potentials and the reduction of end-plate potentials amplitude of the neuromuscular junction, evoked by nerve stimulation. Because 2-nitropropane showed inhibitory effects at peripheral level, we recommend that in work environments where there is exposure to organic solvents, neurological clinical examinations must be performed to detect abnormalities or neurological damage the earlie
Highlights
Organic solvents are chemically different compounds with one common feature: They dissolve fats, oils, resins, cellulose, acetate, and cellulose nitrate, which makes them widely used in industry
The purpose of this study was to investigate the effect of 2-NP on spontaneous and evoked neurotransmission, in vitro, having found an inhibitory neurotoxic effect, which manifested as decreased amplitude and instantaneous frequency of the miniature end-plate potentials (MEPPs), and the amplitude of end-plate potentials (EPPs)
Effect of 2-NP on the resting membrane potential (RMP): A first aspect to consider was to investigate whether 2-NP is able to alter the RMP of muscle cells, because variations in this parameter, per se, can affect the amplitude of post-synaptic potentials
Summary
Organic solvents are chemically different compounds with one common feature: They dissolve fats, oils, resins, cellulose, acetate, and cellulose nitrate, which makes them widely used in industry. Most often organic solvents are used in paint and lacquer industries, in production of pesticides, explosives, plastic, rubber, cellulose, air conditioners, in pharmaceutical industry, and in leather industry [1]. Millions of people around the world are exposed to industrial organic solvents in the manufacturing sectors. Solvents are neurotoxic substances that are detrimental to the functioning of the nervous system [3,4,5]. High-level occupational exposure to volatile organic solvents may elicit various neurotoxic effects [6]. It has previously been shown that some solvents modulate inhibitory transmission and affect synaptic transmission [7,8]
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