Abstract
At present, the stability of drug-loaded micelles is scarcely researched. The effects of different amounts of 2-ethylbutyric acid (EBA) on the interface and micelle behavior of Polyoxyl 15 Hydroxystearate (HS15), Kolliphor RH40, Kolliphor ELP and Tween80 (Polysorbate 80) micelles have been studied in this work. Tanshinone (TAN), a fat-soluble extract of Salvia miltiorrhiza was used as a model drug. The surface properties of drug-loaded micelles have been studied, including critical micelle concentration, minimum adsorption area, pC20 and thermodynamic parameters. The results indicated that the addition of the appropriate amount of EBA contributed to the formation of drug-loaded micelles and improved their physical stability. In addition, the same conclusion can be drawn from determining the absorbance of drug-loaded micelles stored by UV–visible spectrophotometry at different times. The hydrodynamic diameter (dη) of drug-loaded micelles was measured by dynamic light scattering (DLS). The dη values of TAN -loaded micelles with and without EBA were different, indicating that the internal structure of the micellar hydrophobic core had varied. In a word, appropriate amount of EBA added can improve the stability of TAN -loaded micelles, which provides a reference for studying the stability of drug-loaded micelles with nonionic surfactants.
Published Version
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