Abstract
The effect of methoxamine, an agonist at α1-adrenergic receptors, on the frequency of spontaneous activity and parameters of the electrical activity of the atrial myocardium was investigated in rats with normal sinus rhythm and in normal rats under continuous electrical pacing. Methoxamine exerted dual effects on the duration of repolarization of working cardiomyocytes. Methoxamine increased the duration of the repolarization phase of the action potential in normal rats under continuous electrical pacing but decreased it in rats with normal sinus rhythm.
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