Abstract
DDT given orally to adult female rats, at doses between 20 and 200 mg/kg, was shown to have drastic effects on the acetate metabolism. The normal elimination pattern of the expired 14CO 2 from 14C-labeled acetate was distorted, and the rate of output of the 14CO 2 was decreased. The ratio of two labeled urinary metabolites, urea, and one unknown compound, was also affected by DDT. Both these effects were dependent upon the dosage level and time of postadministration. DDT affected differently the incorporation of C-1 and C-2 carbons of acetate molecules into unknown metabolites, suggesting that these two carbons may go through different pathways of metabolism. No such effect was observed when labeled acetate was given intraperitoneally, suggesting that active absorption and transport by the intestinal tract may be involved.
Published Version
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