Effect and mechanism of modified Dachengqi Decoction on gastrointestinal motility in dyspepsia mice

Abstract

Objective: To study the effect of Modified Dachengqi decoction and Dachengqi decoction on gastrointestinal motility in dyspepsia mice. Method: Mice were randomly divided into 5 groups: control group (normal saline), model group (normal saline), Dachengqi decoction group (0.054 g kg -1), Modified Dachengqi decoction group (0.084g kg -1) and Motilium group (0.17 ml kg -1).Result:Compared with the normal group, the myenteric tension of small intestine increased significantly, and the small intestine propulsion rate decreased significantly (P < 0.05).Compared with the model group, the myenteric tension of small intestine in Dachengqi decoction group decreased significantly (P < 0.05), the myenteric tension of small intestine muscle in Modified Dachengqi decoction group decreased significantly, and the small intestinal propulsion rate increased significantly (P < 0.01). And in these two groups, the serum MDA levels decreased significantly, and the serum SOD activity increased significantly (P < 0.01).Conclusion: Modified Dachengqi decoction can improve gastrointestinal stagnation in dyspepsia mice, and its mechanism may be related to the regulation of oxidative stress in dyspepsia mice.