Abstract
Pomegranate (Punica granatum) contains high level of antioxidant. The aim of this study is to evaluate the effect of pomegranate extract on MDA level and histopatological findings in rat’s heart vessel that is exposed to cigarette smoking. Experimental study included sprague dawley rats that were exposed to cigarette smoke 2-3 hours a day for 2 weeks. The rats were divided into 3 groups: the first group was a control group, the second group received 5% pomegranate extract, and the third group was given 10% pomegranate extract. Measurement of MDA levels was done before and after the intervention (at the 8th day and 15th day). The MDA levels were significantly higher in control group than those among intervention group (p<0,05). Histopathological finding showed damage of endothelial cell and microhemorrhagic in rat’s heart vessel due to tissue hypoxia.
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