Abstract
This study investigated whether supplementation with high doses of creatine and caffeine, alone or in combination, affects the bone breaking force of exercised rats. Rats were randomly divided into 8 groups: Sedentary or Exercised (placebo, creatine, caffeine or creatine plus caffeine). The supplemented groups received creatine (load: 0.430 g/kg body weight, for 7 days; and maintenance: 0.143 g/kg for 35 days), caffeine (10 mg/100g body weight, for 35 days) or creatine plus caffeine. The exercised groups underwent a vertical jump training in water (4 sets of 10 jumps interspersed with 1 min resting intervals, 5 days/wk), for 6 weeks. Caffeine ingestion reduced the femur´s width, weight and breaking force, independently of exercise. Caffeine and creatine plus caffeine increased the urinary calcium excretion. Jumping exercise increased the bone breaking force independently of supplementation; nevertheless it did not change the weight and dimensions of the femur of the animals.
Highlights
DOHERTY, M. et al Caffeine is ergogenic after supplementation of oral creatine monohydrate
This study investigated whether supplementation with high doses of creatine and caffeine, alone or in combination, affects the bone breaking force of exercised rats
Rats were randomly divided into 8 groups: Sedentary or Exercised
Summary
Diariamente os animais dos grupos SCr e ECr foram suplementados com creatina e os dos grupos SCrCaf e ECrCaf receberam suplementação de creatina e cafeína, adotandose o procedimento de duas fases: carga e manutenção. Aos grupos SCr, ECr, SCrCaf e ECrCaf foi ministrada uma dose de creatina em pó (Sigma®, 0,430g/kg p.c.) por dia, misturada à dieta. Nesta fase os grupos SCr, ECr, SCrCaf e ECrCaf receberam uma dose de creatina (0,143g/kg p.c.) por dia, misturada à dieta, suficiente para aumentar a quantidade de proteína muscular em ratos (FRANCO et al, 2007, 2011). A suplementação com cafeína iniciou-se na segunda semana, na qual os grupos SCaf, ECaf, SCrCaf e ECrCaf receberam uma dose de cafeína em pó (Sigma®, 10mg/100g p.c.) por dia, misturada à dieta, dosagem suficiente para aumentar a excreção urinária de cálcio em ratos (GOMES et al, 2010). Há evidências de que o treinamento por seis semanas promove adaptações importantes em ratos (FRANCO et al, 2007, 2011)
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