Abstract
ABSTRACT The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism. Keywords : rat, Wistar, semicarbazide, osteolathyrism REFERENCIAS 1992, que aprova as normas tecnicas de proteccao dos FELASA. FELASA, The Federation of Laboratory Animal Science Associations, 2010. Disponivel em . Acessado em: 12 out. 2010. GARDNER, A.F.; DASLER, W.; WEINMANN, J.P. Masticatory apparatus of albino rats in experimental lathyrism.
Highlights
The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats
In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement
Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism
Summary
The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats.
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