Efecto de la arginina 8%-carbonato de calcio y del fluoruro de sodio al 5% en la reducción de la hipersensibilidad dentinaria post terapia periodontal: ensayo clínico

Abstract

AimThe aim of this clinical study was to evaluate and to compare the efficacy in reducing the dentine hypersensitivity of an 8% arginine, calcium carbonate, 1.450ppm sodium monofluorophosphate dentifrice with topical application and twice-daily brushing, with a negative control toothpaste containing calcium carbonate and 1.450ppm fluoride as MFP, after periodontal treatment (baseline) and four weeks respectively. MethodsA fourweek clinical study with 20 subjects with diagnosis of slight to moderate chronic periodontitis under mechanical periodontal treatment and presence of gingival recessions in incisors, canines or premolars, stratified based on baseline tooth sensitivity. Subjects brushed with either a 1.450 ppm fluoride dentifrice or a marketed 8% arginine calcium carbonate dentifrice twice daily for approximately one minute. At screening, baseline and weeks four, subjects’ tooth sensitivity was determined through both evaporative (Schiff and Visual Analogue Scale [VAS]). The same examiner throughout the study performed subject assessments using each stimulus. ResultsBoth subject groups exhibited significant reductions from baseline to four weeks in dentine hypersensitivity. However, patients who received 8% arginine calcium carbonate therapy, exhibited a greater reduction, with a 60% of individuals lacking of pain and with a final median of 0 in comparison with the 5% fluoride varnish and fluoride toothpaste group in which a 100% of subjects felt some degree of pain, presenting a final medium VAS scale of 2.