EEG Driven Autonomous Injection System For An Epileptic Neuroimaging Application.

Abstract

Seizure episodes are frequently observed for adults and children suffering from medically refractory epilepsy and the events remain debilitating unless treated with a more comprehensive approach. Ictal perfusion studies with single-photon emission computed tomography (SPECT) is one of the non invasive imaging modality that has been extensively used to adequately localize the seizure focus. Current practices include the tracer injection within a short time interval at the onset of seizure to generate desirable SPECT scan quality with accurate information on foci region. However, the onset of a seizure is a highly unpredictable event and also with added subclinical events, the overall procedure makes it difficult to administer the tracer manually within the ideal time frame.Hence a complete autonomous injection of radioactive tracer element without manual intervention is expected to offer a highly accurate epileptical focus region and aids in further management of the patient. Electroencephalogram (EEG) physiological signals in the preictal phase contain sufficient indicators to predict the seizure event. The proposed injection system works on the seizure prediction model from the EEG signals to release the dosage, making the system completely autonomous in action. The accuracy of the prediction model based on the publicly available seizure embedded EEG datasets was designed to achieve 94% accuracy, and the model was deployed on an edge system. The syringe based injection system was characterized to emulate dosage release action with minimum volumetric error, and low injection time, on predicting seizure Ictal event from the EEG signal. The proposed system is a step towards developing an autonomous injection system for epileptic neuroimaging applications in hospital settings.Clinical relevance- Autonomous injection of tracer dosage for obtaining accurate and high quality Ictal SPECT scan results is preferred over the manual operation in clinical and hospital residential settings as a part of pre-surgical evaluations. The EEG signal based early prediction of seizure ensures adequate time for radioactive tracer element to reach the brain cells and eventually helps to accurately localize the onset region of seizure in the brain. The EEG driven automated injection system for the noninvasive Ictal SPECT method is clinically important as a pre-surgical evaluation in MRI negative or discordant cases for further surgical actions.