Abstract

Faricimab is a bispecific antibody targeting ANG-2 and VEGF for the treatment of diabetic macular edema (DME). In the YOSEMITE and RHINE trials, patients treated with faricimab in a Treat & Extend (T&E) regime required less frequent treatments compared to Aflibercept given every eight weeks (Q8W) with non-inferior vision changes. However, clinical practice in DME in Canada is typically characterized by pro re nata (PRN) regimens as well as T&E. This research aims to assess the cost-effectiveness of faricimab vs. anti-VEGF treatments applied in such regimens.

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