Editors' Selections from Relevant Scientific Publications

Abstract

Highlights from the Literature| August 01 2022 Editors' Selections from Relevant Scientific Publications Author & Article Information Online ISSN: 1940-6215 Print ISSN: 1940-6207 ©2022 American Association for Cancer Research2022American Association for Cancer Research Cancer Prev Res (Phila) (2022) 15 (8): 473. https://doi.org/10.1158/1940-6207.CAPR-15-8-HFL Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record August 1 2022 Citation Editors' Selections from Relevant Scientific Publications. Cancer Prev Res (Phila) 1 August 2022; 15 (8): 473. https://doi.org/10.1158/1940-6207.CAPR-15-8-HFL Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Malignant melanoma (by Nephron via Wikimedia Commons) A mouse study shows that proinflammatory topical therapy can shrink giant nevi: large, pigmented areas of skin that can become cancerous. In humans, giant nevi can cover up to 80% of the body’s surface and progress to melanomas 12% of the time. Choi et al. developed a genetically modified mouse model of giant nevi that developed pigmented skin patches and melanoma. They then treated the pigmented areas with inhibitors of the signaling molecules MEK, PI3K and c-KIT, or squaric acid dibutylester (SADBE), a topical treatment that induces inflammation and recruits macrophages. These treatments cleared much of the pigmentation and SADBE treatment eliminated the risk of melanoma. SADBE was also effective at treating patches of human nevi that had been grafted onto mice, suggesting that topical therapies that induce this type of inflammation could be developed to treat children with congenital giant nevi. Choi... You do not currently have access to this content.