Editors' Selections from Relevant Scientific Publications

Abstract

Highlights from the Literature| April 03 2023 Editors' Selections from Relevant Scientific Publications Author & Article Information Online ISSN: 1940-6215 Print ISSN: 1940-6207 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Prev Res (Phila) (2023) 16 (4): 185. https://doi.org/10.1158/1940-6207.CAPR-16-4-HFL Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record April 3 2023 Citation Editors' Selections from Relevant Scientific Publications. Cancer Prev Res (Phila) 1 April 2023; 16 (4): 185. https://doi.org/10.1158/1940-6207.CAPR-16-4-HFL Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Immune cells in colorectal cancer (by Juha P. Väyrynen et al via Cancer Immunology Research) A spatial survey of gene expression and proteomic changes in early-stage colorectal cancer reveals molecular and immunological features during tumorigenesis. Using digital spatial profiling and imaging mass cytometry, Roelands et al. analyzed normal, precancerous, and cancerous tissue samples from patients with early-stage disease and identified differentially expressed genes in the epithelium and stromal segments. They found that innate immune responses were activated early during malignant transformation, and there was a shift of immune cell composition from pro-inflammatory to immune-suppressive macrophage populations from normal tissue through dysplasia to cancer. These findings shed light on the stepwise progression of colorectal cancer and suggest that the approach could aid in identifying biomarkers for early detection and interception. Roelands J, … de Miranda NFCC. Gut. 2022 Nov 28:gutjnl-2022-327608. Small cell lung cancer (by Yale Rosen via Wikimedia Commons)... You do not currently have access to this content.