Abstract
The neurotrophic tyrosine receptor kinases (TRK) are membrane-bound receptors that regulate the growth, differentiation, and programmed cell death of neurons in the peripheral and central nervous systems. The TRK family includes TRKA (encoded by NTRK1), TRKB (encoded by NTRK2), and TRKC (encoded by NTRK3) proteins. Each TRK protein contains an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain [1]. Chimeric NTRK fusions are generally caused by chromosomal rearrangements resulting in the fusion of a 5’-partner gene with a 3’ NTRK gene that retains the entire tyrosine kinase domain.
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