Abstract
In cultures containing mixed populations of mammalian somatic cells, two cells of diverse origin may fuse and produce mono-nucleated hybrid descendants that can be grown indefinitely. Even cells of different species can be hybridized in this way. The nature of the human-mouse hybrid cell lines that Mary Weiss and I prepared in 19671 suggested that these hybrids could be used to determine in which chromosome a particular human gene is located. The property that distinguished the human-mouse lines from other interspecies hybrids made earlier in the laboratory of Ephrussi2 was that during growth, they eliminated human chromosomes preferentially. Since conditions . . .
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