Abstract
Editorial: Plasticity of GABAergic synapses.
Highlights
For long time, plasticity of brain circuits has been hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses have been assumed to be relatively invariant
The 14 articles presented in this ebook cover the mechanisms of inhibitory synaptic plasticity, at the molecular and microcircuit levels
A similar conceptual approach, based on the analysis of receptor dynamics, has been adopted by Muir and Kittler (2014) to investigate inhibitory plasticity in relation to GABAA receptor diffusion at inhibitory synapses located in the axon initial segment
Summary
Plasticity of brain circuits has been hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses have been assumed to be relatively invariant. 1 Neuroscience and Brain Technologies, Post-synaptic Mechanisms of GABAergic Transmission, Fondazione Istituto Italiano di Tecnologia, Genova, Italy, 2 Inserm U 1127, Centre National de la Recherche Scientifique UMR 7225, Sorbonne Universités UPMC Paris 06, UMR S 11, Paris, France, 3 Institut du Cerveau et de la Moelle Épinière, Paris, France Inhibition should be exclusively modulated by the differential glutamatergic-driven activation of a highly diverse population of inhibitory interneurons displaying specific temporal dynamics and selective innervation patterns.
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