Editorial: Neuroplasticity and Extracellular Proteolysis.

Jerzy W Mozrzymas,Leszek Kaczmarek

doi:10.3389/fncel.2016.00059

Abstract

Editorial: Neuroplasticity and Extracellular Proteolysis.

Highlights

For long investigations of neuroplasticity and research into the role of extracellular proteolysis have been progressing largely separately but their recent progress was paralleled by a growing awareness that neuronal networks form a functional partnership with glia and extracellular matrix (ECM) and a term “tetrapartite synapse” was coined (Dityatev and Rusakov)
Et al observed no change in the morphology of existing dendritic spines, spine dynamics were altered in MMP-9 KO mice
MMP-9 function at the spines appears to be mediated by cleavage of cell adhesion molecules (CAM) and integrin signaling

Summary

Introduction

For long investigations of neuroplasticity and research into the role of extracellular proteolysis have been progressing largely separately but their recent progress was paralleled by a growing awareness that neuronal networks form a functional partnership with glia and extracellular matrix (ECM) and a term “tetrapartite synapse” was coined (Dityatev and Rusakov). Extracellular proteolysis emerges as a key mechanism in mediating interactions between these players and description of this cross-talk opens new avenues in exploring physiological and pathological mechanisms in the CNS.

Results

Conclusion