Abstract
Editorial: Golgi Pathology in Neurodegenerative Diseases
Highlights
Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
The Golgi apparatus is a central organelle that lies at the heart of the secretory pathway sustaining the delivery of proteins from their site of synthesis in the endoplasmic reticulum to their final destination, the extracellular medium, the plasma membrane, and the endo-lysosomal system
The mammalian Golgi apparatus was first described by Camillo Golgi in 1998 as “apparato reticolare interno,” “a fine and elegant network within the cell body . . . completely internal in the nerve cells” (Golgi, 1898a,b)
Summary
Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience. Structural and functional alterations of the Golgi apparatus, which are here collectively termed Golgi pathology, are recognized as a constant pathological hallmark of various neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Parkinson, Alzheimer, Huntington, and prion diseases (Fan et al, 2008).
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