Abstract
Editorial: Genetics and epigenetics of fetal alcohol spectrum disorders.
Highlights
Specialty section: This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Genetics
Children born to mothers who drink during pregnancy are at risk for growth retardation, memory, learning, and cognitive deficits under a lifelong disability known as Fetal Alcohol Spectrum Disorders (FASD), which occurs at a high rate in the US (∼1/100 live births) and worldwide
There are three outstanding features of FASD. (a) Humans have been associated with alcohol consumption dated as far back as 7000 BC (McGovern et al, 2004) and there is no sign of waning. (b) FASD can range across a large spectrum of severity, from the more severe Fetal Alcohol Syndrome (FAS) to the hard to detect, subtle mental dysfunctions
Summary
Specialty section: This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Genetics. There is strong evidence to indicate that genetic makeup is a major contributing factor to the differential vulnerability to FASD. Current evidence points to alcohol’s influence on the interaction of genetic and epigenetic factors.
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