Editorial: Emerging roles and mechanisms of stromal cells in carcinomas at the molecular level

Abstract

For an extended period, the tumor microenvironment (TME) has not been focused on in the field of 20 cancer biology before Stephen Paget's "seed and soil" hypothesis [1]. The representative characters of 21 cells involved in TME are high plasticity and continuous phenotypic and functional change. For 22 example, the desmoplastic reaction in pancreatic cancer is a critical histological observation, tightly 23 associated with significantly increasing the interstitial fluid pressure within the tumor niche.