Abstract
In this retrospective cohort, the authors report that increased numbers of transrectal prostate needle biopsies did not increase the sensitivity, specificity, or positive or negative predictive value of detecting a Gleason grade/pattern ≥4 at subsequent radical prostatectomy. 1 Quintana L. Ward A. Gerrin S.J. et al. Gleason misclassification rate is independent of number of biopsy cores in systematic biopsy. Urology. 2016; https://doi.org/10.1016/j.urology.2015.12.089 Abstract Full Text Full Text PDF PubMed Scopus (21) Google Scholar Two main reasons for this finding were the presence of a high-grade tumor in a region not generally targeted by conventional 12-core or saturation biopsies (eg, anterior region) or the presence of a very small high-grade component. These data add to the growing evidence that a biopsy method specifically targeting high-grade components of a prostate cancer (such as emerging magnetic resonance imaging biopsy technologies) may offer greater potential to increase detection of clinically significant cancers than simply increased numbers of standard biopsies.
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