Abstract
The successful use of intravesical injections of botulinum toxin for neurogenic bladder disorders has been well reported. The mechanisms are not clearly understood, but BTX-A decreases acetylcholine release at the presynaptic level, leading to a decrease in detrusor contractility. Recently, Giannantoni et al.1 Giannantoni A. Di Stasi S.M. Nardicchi V. et al. Botulinum-A toxin injections into the detrusor muscle decrease nerve growth factor bladder tissue levels in patients with neurogenic detrusor overactivity. J Urol. 2006; 175: 2341-2344 Abstract Full Text Full Text PDF Scopus (123) Google Scholar reported that intravesical BTX-A treatment induces a state of nerve growth factor deprivation in bladder tissue that persists for up to 3 months. Intravesical injection of botulinum toxin type A: Management of neuropathic bladder and bowel dysfunction in children with myelomeningoceleUrologyVol. 68Issue 5PreviewTo evaluate the efficacy of botulinum toxin A in the treatment of children with detrusor hyperreflexia caused by myelomeningocele and the effects of this treatment on neuropathic bladder and bowel dysfunction. Full-Text PDF
Published Version
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