Abstract
Editorial: Breaking the cycle: attacking the malaria parasite in the liver.
Highlights
Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology
The anatomic site of priming of naive Plasmodium-specific CD8 T cells, be it in the lymph nodes draining the site of Plasmodium antigen deposition by the mosquito or in the liver, may determine the specificity of the effector CD8 T cells
A better understanding of fine specificity and quantities of antibodies required for protection and the antigens recognized by neutralizing antibodies will facilitate the design of refined malaria vaccines that induce robust, long-lived, protective B cell responses (Dups et al, 2014)
Summary
Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium from the liver. How effector CD8 T cells detect the few infected hepatocytes in the large liver and the mechanisms they use to kill the intracellular parasites are unknown.
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