Editorial: Brain cholinergic mechanisms.

Sukumar Vijayaraghavan,Geeta Sharma

doi:10.3389/fnsyn.2015.00014

Abstract

Editorial: Brain cholinergic mechanisms.

Highlights

Unlike what we know about glutamatergic transmission, neither the prevalence of fast cholinergic transmission or postsynaptic specializations at cholinergic synapses, is well understood
Receptor localizations within and among neurons, along with transmitter source and access to receptors, provide for a system that is capable of neuromodulation at multiple time scales that allow for short- and long-term regulation of circuit output in the brain
The compilation of reviews and primary papers in this research topic provides a sampling of findings at different levels of integration that highlight both the current status of our understanding of central nervous system (CNS) cholinergic mechanisms as well as reveals the gaps in our knowledge that need to be filled

Summary

Introduction

Receptor localizations within and among neurons, along with transmitter source and access to receptors, provide for a system that is capable of neuromodulation at multiple time scales that allow for short- and long-term regulation of circuit output in the brain. The compilation of reviews and primary papers in this research topic provides a sampling of findings at different levels of integration that highlight both the current status of our understanding of CNS cholinergic mechanisms as well as reveals the gaps in our knowledge that need to be filled.

Results

Conclusion