Abstract
Despite a distinctive immunofluorescence picture, anti-TBM antibody accumulation in human renal disease was recorded only after descriptions of experimental models of anti-TBM disease. Immunization of guinea pigs or certain strains of rats with appropriate renal tubular basement-membrane (TBM) preparations in adjuvant results in severe renal disease, characterized by tubular damage and interstitial inflammation.1 2 3 The immunofluorescence findings are highly characteristic: completely continuous (linear) accumulation of IgG, and usually of C3, is seen along the TBM (both proximal and distal). (Immunization of rabbits or rats with soluble extracts of kidney or exogenous antigens may also lead to immune-complex deposition along the TBM; . . .
Published Version
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