Abstract

Edible Bird’s Nest (EBN) is the most prized health delicacy among the Chinese population in the world. Although some scientific characterization and its bioactivities have been studied and researched, no lights have been shed on its actual composition or mechanism. The aim of this review paper is to address the advances of EBN as a therapeutic animal bioproduct, challenges and future perspectives of research involving EBN. The methodology of this review primarily involved a thorough search from the literature undertaken on Web of Science (WoS) using the keyword “edible bird nest”. Other information were obtained from the field/market in Malaysia, one of the largest EBN-producing countries. This article collects and describes the publications related to EBN and its therapeutic with diverse functional values. EBN extracts display anti-aging effects, inhibition of influenza virus infection, alternative traditional medicine in athletes and cancer patients, corneal wound healing effects, stimulation of proliferation of human adipose-derived stem cells, potentiate of mitogenic response, epidermal growth factor-like activities, enhancement of bone strength and dermal thickness, eye care, neuroprotective and antioxidant effects. In-depth literature study based on scientific findings were carried out on EBN and its properties. More importantly, the future direction of EBN in research and development as health-promoting ingredients in food and the potential treatment of certain diseases have been outlined.

Highlights

  • Edible Bird’s Nest (EBN) is a secretion created by swiftlets

  • The discussion in this article proves EBN could be a source of vital health-promoting ingredients with the reported content of amino acids, proteins, carbohydrates, fatty acids and minerals

  • The extract based on active ingredients or a standardized operating procedure should be filed

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Summary

Introduction

Edible Bird’s Nest (EBN) is a secretion created by swiftlets. Erodramus (echolocating swiftlets) and Collocalia (non-echolocating swiftlets) are among the two genera of swiftlets known to produce valuable EBN (Ma and Liu, 2012). Type II collagen, aggrecan and SOX-9 gene expression and total sulfated glycosaminoglycan production were increased Low concentration of EBN synergistically induced cell proliferation, especially in serum-containing medium. EBN and its content (lactoferrin and ovotransferrin) attenuated H2O2induced cytotoxicity and decreased radical oxygen species through increased scavenging activity EBN demonstrated protective effects against hydrogen peroxide-induced toxicity and cell oxidative stress on SHSY5Y cells.

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Conclusion

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