Abstract
Objectives: To investigate an eco-friendly method to enhance the solubility of Mefenamic acid. The present investigation was to employ these hydrotropic solutions to extract the drugs from their dosage forms, precluding the use of costlier and harmful organic solvents. Methodology: Mefenamic acid was analyzed by using UV Visible spectrophotometer (Model 1800, Shimadzu), and its solubility (poorly water-soluble drug) measured by mixed solvency method. Sodium caprylate solution was used as a hydrotropic solubilizing agent. Findings: The solubility of the Mefenamic acid drug in water was very low at about 0.2 mg/ml and the solubility of Mefenamic acid in the 20% sodium caprylate solution was 10 mg/ml. The value of percentage estimation obtained was from 98.6 (tablet II) to 98.8 (tablet I). This value is obtained near to 100% hence, we can say that the proposed method is correct. Standard deviation (0.173 to 0.346), percentage coefficient of variation (0.175 to 0.350) and the value of standard error (0.101 to 0.202) are also very low to validate the accuracy of the proposed method. Novelty: Mixed solvency concept can be utilized for spectrophotometric estimation of poorly water-soluble drugs from their bulk drug samples to avoid the use of organic solvents that provide a new, economical, environmentally friendly, safe, and reliable analytical mechanism. Keywords: Mixed solvency; solubility; hydrotropic; mefenamic acid; sodium caprylate
Highlights
Solubility is an important parameter in drug formation
The mixed solvency concept is an effective technique for the enhancement of the solubility of poorly water-soluble drugs by using a solubilizing technique, we can preclude the use of organic solvents, which are more costly, toxic, and harmful to our environment [6,7,8,9]
It may be assumed that it is possible to use the mixed solvency technique to replace the use of an organic solvent that is more expensive and harmful for our atmosphere
Summary
Solubility is an important parameter in drug formation. Many drugs have very low solubility in water. It is necessary to increase the solubility of these drugs [1,2]. Mefenamic acid is a non-steroidal anti-inflammatory drug and its solubility in water is very low at about 0.2 mg/ml [3]. The mixed solvency concept is an effective technique for the enhancement of the solubility of poorly water-soluble drugs by using a solubilizing technique, we can preclude the use of organic solvents, which are more costly, toxic, and harmful to our environment [6,7,8,9]. The solubility of the drug can be
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