Abstract
Objectives: Mefenamic acid is used as a modal nonsteroidal anti-inflammatory drug for analytical estimation. Due to the poor aqueous solubility, mefenamic acid liberated reduced bioavailability.
 Methods: The hydrotropic solubilization technique is a promising technique used to improve the solubility of water-insoluble drugs. Experimentally, 2 M sodium benzoate has been employed in the prior titrimetric estimation of mefenamic acid and shows synergistic enhancement in the solubility of mefenamic acid by many folds as compared to the distilled water. Similarly, sodium benzoate approach was further applied in analytical estimation of marketed oral dosage forms in tablets, capsules, and suspension for checking the reproducibility of applied approach by ultraviolet (UV) method. Validation of UV method was further done and checked for linearity, accuracy, and precision. Drug degradation studies were also performed successfully to investigate the sustainability of mefenamic acid in various dosage forms under various stress conditions and to establish the preferred storage conditions for the drug.
 Results: In the present experimental investigation, obtained mean % recoveries were close to 100 indicating the accuracy of the proposed approach. Similarly, in analytical estimation of mefenamic acid in oral marketed forms, results have reported lower values of standard deviation, % coefficient of variation, and standard error facilitated the reproducibility and precision of the proposed approach in the titrimetric estimation and analytical validation of UV method mefenamic acid in bulk and marketed forms.
 Conclusion: Therefore, a new, simple, precise, and inexpensive proposed method was executed by validating the result statistically.
Highlights
Mefenamic acid as an individual from the anthranilic acid class or fenamates class of nonsteroidal anti-inflammatory drugs used in the treatment of gentle to direct pain and irritation in rheumatic illnesses, osteoarthritis, intense pain like muscle and back pain, toothache, and in menorrhagia
Preliminary solubility studies of drug The enhancement in solubility of 100-fold was reported for mefenamic acid in hydrotropic mixture solution of 2 M sodium benzoate as compared to solubility in distilled water
The stability of mefenamic acid in sodium benzoate solution was evaluated by keeping the solution at room temperature conditions for 24 h of duration
Summary
Mefenamic acid as an individual from the anthranilic acid class or fenamates class of nonsteroidal anti-inflammatory drugs used in the treatment of gentle to direct pain and irritation in rheumatic illnesses, osteoarthritis, intense pain like muscle and back pain, toothache, and in menorrhagia. The bioavailability problem with BCS Class II drugs can be overcome by increasing the solubility and dissolution rate of the drug in the gastrointestinal fluids [2,6-9]. As in this regard, improving the solubility of such drugs, the use of “Hydrotropes” has shown the remarkable ability in improving the bioavailability of mefenamic acid. By representing weak van der Waals association and intermolecular hydrogen, authority assists in bringing striking dissolvability and effectiveness of the hydrotrope which dependent on its dissolvability improvement proportion of drug candidate and has an impact on their dissolvable properties. Both methods are suggested to apply successfully for routine analysis of the drug
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