Abstract
In this paper, a new strategy towards the synthesis of caffeic acid phenethyl ester (CAPE) is introduced. The reaction is carried out in a deep eutectic solvent made of caffeic acid and choline chloride. Caffeic acid is used as part of the solvent and as reactant. Phenethyl alcohol is soluble in this mixture in every molar ratio, and as a consequence no additional solvent is necessary. Reaction conditions were optimised with respect to the molar ratio of phenethyl alcohol and caffeic acid, and by varying the amount and nature of the acid catalyst as well as the reaction time. The obtained CAPE ester could easily be separated from the reaction mixture by simply adding water to destroy the deep eutectic by solubilisation of choline chloride in the aqueous phase.
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