Abstract
Background Previous studies have suggested that acute allograft rejection is associated with increases in QT/QTc. Purpose This study sought to determine the relationship between acute allograft rejection and ECG changes in patients undergoing an orthotopic heart transplant. Methods The study population consisted of 220 adult heart transplant patients enrolled in the NEW HEART Study. ECGs performed within 72 h of endomyocardial biopsy were analyzed with ECGs obtained Results Among the 151 male and 69 female transplant recipients (age 54 ± 13), there were 969 biopsy/ECG pairs: 677 with no rejection, 280 with mild rejection, and 12 with moderate/severe rejection. Moderate/severe rejection was associated with significant increases in QRS duration (p Conclusions Moderate/severe acute allograft rejection is associated with ECG changes following transplant surgery. Future studies are needed to assess the value of computerized ECG measurement algorithms for detecting acute allograph rejection.
Published Version
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