Abstract
This review summarizes the most noteworthy achievements in the field of C–O and C–N bond formation by hydroalkoxylation and hydroamination reactions on unactivated alkenes (including 1,2- and 1,3-dienes) promoted by earth-abundant 3d transition metal catalysts based on manganese, iron, cobalt, nickel, copper and zinc. The relevant literature from 2012 until early 2021 has been covered.
Highlights
The prevalence of ether and amine motifs in various areas of chemistry, such as bulk and fine chemicals, biological and pharmaceutical chemistry or catalysis, has driven the development of original and innovative methods for their efficient synthesis [1,2]
This review has put forward the most relevant advances of the last decade in the addition of E–H (E = O, N) σ–bond onto unactivated alkenes, 1,2- and 1,3-dienes promoted by manganese, iron, cobalt, nickel, copper and zinc catalysis
It is unquestionable that earthabundant 3d metals have played a major role in the latest developments of metal-catalyzed alkene hydrofunctionalization as witnessed by the burgeoning activity highlighted
Summary
The prevalence of ether and amine motifs in various areas of chemistry, such as bulk and fine chemicals, biological and pharmaceutical chemistry or catalysis, has driven the development of original and innovative methods for their efficient synthesis [1,2] Among these methods, the most attractive and atom-economical approach towards these prevalent motifs is undoubtedly the addition of E–H (E = O, N) σ-bond onto unactivated alkenes, referred to as alkene hydrofunctionalization [3,4,5,6,7,8,9]. The achievements are summarized according to the nature of the 3d transition metal and the type of hydrofunctionalization reaction
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