Abstract
ObjectiveIn this study, we aimed to highlight the common early‐stage clinical and laboratory variables independently related to the acute phase duration in patients with uncomplicated coronavirus disease (COVID‐19) pneumonia.MethodsIn hospitalized patients, the acute phase disease duration was followed using the Brescia‐COVID respiratory severity scale. Noninvasive ventilation was administered based on clinical judgment. Patients requiring oropharyngeal intubation were excluded from the study. For parameters to be measured at the hospital entrance, age, clinical history, National Early Warning Score 2 (a multiparametric score system), partial pressure of oxygen in arterial blood/fraction of inspired oxygen (P/F ratio), C‐reactive protein, and blood cell count were selected.ResultsIn 64 patients, age (direct relationship), P/F, and platelet number (inverse relationship) independently accounted for 43% of the acute phase duration of the disease (P < .001).ConclusionsFor the first time, the present results revealed that the acute phase duration of noncomplicated pneumonia, resulting from severe acute respiratory syndrome coronavirus 2, is independently predicted from a patient's age, as well as based on the hospital entrance values of P/F ratio and peripheral blood platelet count.
Highlights
Following the severe acute respiratory syndrome (SARS) owing to the coronavirus 2 (SARS-CoV-2) pandemic, a huge proportion of the general population is expected to require complex medical care as approximately 14% of patients develop the severe disease, requiring hospitalization 1.to properly allocate medical resources, simple clinical or laboratory predictors identifying disease gravity at the first contact of patients with hospital facilities are required.Apart from common disease signs and symptoms, organized in multiparametric score systems, optimal laboratory variables should be considered indices for systemic inflammation, including C-reactive protein (CRP), white blood cell (WBC) count, and platelet count, known to be related to the hematologic impact of the disease, with PaO2 accounting for lung function
All these parameters were altered in coronavirus disease (COVID-19) pneumonia
We aimed to identify early-stage, commonly available clinical and laboratory variables related to the duration of the acute phase in uncomplicated COVID-19 pneumonia
Summary
Following the severe acute respiratory syndrome (SARS) owing to the coronavirus 2 (SARS-CoV-2) pandemic, a huge proportion of the general population is expected to require complex medical care as approximately 14% of patients develop the severe disease, requiring hospitalization 1. Apart from common disease signs and symptoms, organized in multiparametric score systems, optimal laboratory variables should be considered indices for systemic inflammation, including C-reactive protein (CRP), white blood cell (WBC) count, and platelet count, known to be related to the hematologic impact of the disease, with PaO2 accounting for lung function. All these parameters were altered in coronavirus disease (COVID-19) pneumonia. Owing to the short time of disease outbreak, prediction models for COVID-19 are poorly reported and present a high risk of bias, necessitating urgent collaborative efforts to develop more rigorous models 3
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