Early stage atherosclerosis regression, using b- mode ultrasound- guided chlor- aluminium sulfonated phthalocyanine - mediated catheter- based low level red laser photodynamic therapy

Abstract

Background and Aims : Excessive lipid accumulation by macrophages plays a crucial role in atherosclerosis. Foam cells are generated by uncontrolled uptake of modified LDL, especially oxidized LDL (oxLDL). Photodynamic therapy is a treatment that uses photosensitizing agents, along with light to kill cancerous and hyperplasia cells.The aim of this study was to evaluate the effect of chlor- aluminium sulfonated phthalocyanine (CASPc)- mediated photodynamic therapy on early stage atherosclerotic regression, wherein diagnostic B- mode ultrasound is combined with laser system, with a goal of increased safety.