Abstract
Gaebel, Wolfgang, Bruno Müller-Oerlinghausen and Jürgen Schley: Early Serum Levels of Neuroleptics do not Predict Therapeutic Response in Schizoprenia. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1992, 16(6): 891–900. 1. 1. Thirty-six acute schizophrenics were included in a 28-day open treatment study with the neuroleptic perazine. 2. 2. Peak serum levels of parent drug and its main inactive metabolite desmethyl-perazine were assessed 2 hours after an oral test dose given at the beginning of the study. 3. 3. Whereas peak levels of perazine were not significantly different in treatment responders and nonresponders, desmethylperazine was significantly higher in nonresponders. 4. 4. The ratio between desmethylperazine and perazine was not predictive of (non-)response to neuroleptic treatment in schizophrenia.
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