Abstract
Background: Post-stroke depression (PSD) constitutes an essential complication of stroke and is associated with high-risk unfavorable outcome after stroke. The main objective of this prospective study was to determine the relationship between early-onset PSD (1 month after stroke) and functional outcomes 5 years after baseline enrollment.Methods: Four hundred thirty-six patients who met the criteria were included in this study from October 2013 to February 2015. The follow-up time for each patient was ~5 years, with follow-up every 3 months. Patients received questionnaires including the 17-item Hamilton Depression Scale (HAMD), the Mini-Mental State Examination (MMSE), the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the Barthel Index (BI).Results: Of the 436 patients, 154 (35.3%) patients with the prevalence of PSD status at baseline, 26 (7.2%) patients with the prevalence of PSD status, and 73 (20.1%) had an unfavorable outcome 5 years after stroke. The odds ratio (OR) for unfavorable outcome at 5 years in the PSD group was ~2.2 relative to the non-PSD group after adjusting for potential risk factors [OR = 2.217, 95% confidence interval (CI) = 1.179–4.421, P = 0.015]. In the early-onset PSD group, HAMD scores were independently associated with 5-year unfavorable outcome rates (OR = 1.168, 95% CI = 1.015–1.345, P = 0.031).Conclusions: Our findings indicate that early-onset PSD status in Chinese patients is an independent risk factor for unfavorable outcome 5 years after stroke, and that the severity of PSD is also related to unfavorable outcome.
Highlights
Post-stroke depression (PSD) has been reported to be one of the most common complications in patients who experienced a stroke [1]
One study by Ayerbe et al elaborated on the association between depression 3 months after stroke and disability at 5 years after stroke from the South London Stroke Register using the Hospital Anxiety and Depression Scale (HADS), Glasgow Coma Scale (GCS), and Barthel Index (BI), but no group of studies reported such a long follow-up of patients with early-onset depression (1 month) and disability using the modified Rankin Scale and Hamilton Depression Scale (HAMD)
In the PSD group, patients had an average age of 61.9 years, and the median National Institutes of Health Stroke Scale (NIHSS) score was 3.5 (IQR, 2–6)
Summary
Post-stroke depression (PSD) has been reported to be one of the most common complications in patients who experienced a stroke [1]. Previous articles have explained that PSD is linked to clinical and functional outcomes. It is associated with highrisk disability and a low quality of life (QoL) in patients with stroke [8,9,10]. PSD will reduce social interactions and reduce the success rate of rehabilitation [9, 11, 12] Most of these studies have limitations, including short follow-up times and small sample sizes. Post-stroke depression (PSD) constitutes an essential complication of stroke and is associated with high-risk unfavorable outcome after stroke. The main objective of this prospective study was to determine the relationship between early-onset PSD (1 month after stroke) and functional outcomes 5 years after baseline enrollment
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
