Abstract
Background / Aims: As estrogens play a neuroprotective role, the decline in their concentrations during menopause may compromise cognitive function in postmenopausal women. Whether early menopause (EM) is associated with an increased risk of dementia remains unclear. The purpose of this study was to systematically review and meta-analyze current evidence regarding the association between EM or premature ovarian insufficiency (POI) and the risk of dementia of any type.
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