Abstract
Traumatic shock may be initiated by hemodynamic and/or metabolic changes in the region of injury. Regional blood flow and its relation to a number of vasodilaflow tor factors in blood from a trauma region was studied in the Vasoactive kinins dog hind leg. Contusion trauma was followed by an immediate and marked increase of blood flow to the traumatized region. This increase of arterial blood flow could be modified by a proteinase inhibitor, aprotinin. This may indicate that , activated by the trauma, take part in lowering the peripheral resistance in the traumatized region. The present study thus suggests a humoral mechanism in the regulation of the regional hemodynamic changes following trauma. It is, however, doubtful whether it is possible to apply this clinically, since the reaction is extremely rapid.
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Schedule a callMore From: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
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