Abstract
Early evolution of resistance to oxidative stress after sub-arachnoid hemorrhages: A cohort study of 50 patients
Highlights
Intracranial aneurisms (ICA) are the main cause of subarachnoid hemorrhages (SAH) and lead to a death toll reaching 40 to 60% of patients, 25 to 40% dying during the first week following their hospital admission
resistance to ROS (RROS) at day 1 (D1) inversely correlated with WFNS
When oxidative stress might play a role [3,28] we demonstrated that RROS was decreased during ischemic strokes [4] and during a preliminary study that resistance to Reactive Oxygen Species (ROS) was increased after SAH [6]
Summary
Intracranial aneurisms (ICA) are the main cause of subarachnoid hemorrhages (SAH) and lead to a death toll reaching 40 to 60% of patients, 25 to 40% dying during the first week following their hospital admission. Among those who will survive 30 to 70% will suffer with various deficits. ROS, generated during inflammatory reactions and/or energy production reactions, must deactivate leading to random deleterious events depending to some extent on each patient specific Resistance to Reactive Oxygen Species (RROS). We analysed the early changes in the resistance to ROS (RROS) as a function of the vital prognosis at Day 15 together with other prognostic markers
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