Abstract
The ISOLPHARM (ISOL technique for radioPHARMaceuticals) project is dedicated to the development of high purity radiopharmaceuticals exploiting the radionuclides producible with the future Selective Production of Exotic Species (SPES) Isotope Separation On-Line (ISOL) facility at the Legnaro National Laboratories of the Italian National Institute for Nuclear Physics (INFN-LNL). At SPES, a proton beam (up to 70 MeV) extracted from a cyclotron will directly impinge a primary target, where the produced isotopes are released thanks to the high working temperatures (2000 °C), ionized, extracted and accelerated, and finally, after mass separation, only the desired nuclei are collected on a secondary target, free from isotopic contaminants that decrease their specific activity. A case study for such project is the evaluation of the feasibility of the ISOL production of 64Cu and 67Cu using a zirconium germanide target, currently under development. The producible activities of 64Cu and 67Cu were calculated by means of the Monte Carlo code FLUKA, whereas dedicated off-line tests with stable beams were performed at LNL to evaluate the capability to ionize and recover isotopically pure copper.
Highlights
The ISOLPHARM project aims at the production of a wide set of high purity radionuclides for medical use, either for diagnosis or for therapy, according to the Isotope Separation On-Line (ISOL) technique, an accelerator-based method currently being implemented at the Legnaro NationalLaboratories of the National Institute for Nuclear Physics
Taking into account the available proton beam energy at SPES and the requirements for the ISOL targets, Zirconium germanide was considered as a new possible target material to produce 64 Cu and 67 Cu in the framework of ISOLPHARM
Zirconium germanide looks as a promising material for ISOL application and is currently under characterization at the Legnaro laboratories
Summary
The ISOLPHARM project aims at the production of a wide set of high purity radionuclides for medical use, either for diagnosis or for therapy, according to the Isotope Separation On-Line (ISOL) technique, an accelerator-based method currently being implemented at the Legnaro National. The ISOLPHARM project will, exploit the SPES Radioactive Ion Beams (RIBs) to produce high quality and high purity radionuclides in Legnaro that could be used for radiopharmaceutical applications. Molecules 2018, 23, 2437 or under construction, are disseminated around the world [3,4,5,6] Thanks to such dissemination of know-how, the ISOL technique was further developed and studied resulting as one of the main techniques for on-line isotope production of high-intensity and high-quality radioactive ion beams [7]
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