Abstract
In his Feb 5 commentary1 on invasive aspergillosis, David Denning refers to a study of Maertens and colleagues,2 in which a prospective screening for circulating galacto-mannan by a sandwich ELISA (Platelia Aspergillus, Sanofi Diagnostics Pasteur, Marnes la Coquette, France) for patients with haematological disorders at high risk for invasive aspergillosis was assessed. The manufacturer of this assay recommends that the optical density (OD) index is calculated for the samples by dividing the OD value of each serum by the OD of a control serum (threshold serum) and to consider an index of 1·5 and above a positive test, an index of 1–1·5 a grey zone result, and an index of less than 1 a negative test.
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