Early detection of autism spectrum disorder via deep-learning application of fMRI and machine learning for ASD children identifications

Abstract

This study unveils an advanced convolutional-neural-network (CNN) algorithm that was meticulously engineered to examine resting-state functional magnetic resonance imaging (fMRI) for early ASD detection in pediatric cohorts. The CNN architecture amalgamates convolutional, pooling, batch-normalization, dropout, and fully connected layers, optimized for high-dimensional data interpretation. Rigorous preprocessing yielded 22,176 two-dimensional echo planar samples from 126 subjects (56 ASD, 70 controls) who were sourced from the Autism Brain Imaging Data Exchange (ABIDE I) repository. The model, trained on 17,740 samples across 50 epochs, demonstrated unparalleled diagnostic metrics – accuracy of 99.39%, recall of 98.80%, precision of 99.85%, and an F1 score of 99.32% – and thereby eclipsed extant computational methodologies. Feature map analyses substantiated the model’s hierarchical feature extraction capabilities. This research elucidates a deep learning framework for computer-assisted ASD screening via fMRI, with transformative implications for early diagnosis and intervention. And, this study addresses the critical need for early detection and intervention in autism spectrum disorder (ASD) using machine learning. Specific therapies are needed for ASD, a neurodevelopmental disease that affects social interaction and communication. To find trends in ASD, our research uses a variety of early childhood screening tests as training sets for machine learning algorithms. The methodology that has been suggested utilizes methods of machine learning to compute the ASD spectrum, considering its many expressions. By using multidisciplinary methods and sophisticated screening instruments, we want to create an accurate system for early ASD detection. Algorithmic transparency, data protection, and ethical considerations are essential. This study seeks to build precise instruments for early ASD detection by promoting collaboration between specialists in neurodevelopment, psychology, and machine learning. A robust instrument that enhances the knowledge of medical practitioners is machine learning. Results show how innovation may transform early interventions and help people on the autistic spectrum achieve enhanced results.