Abstract
e-PKGene (http://www.pharmacogeneticsinfo.org) is a manually curated knowledge product developed in the Department of Pharmaceutics at the University of Washington, USA. The tool integrates information from the literature, public repositories, reference textbooks, product prescribing labels and clinical review sections of new drug approval packages. The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information. The database helps scientists to mine pharmacokinetic and pharmacodynamic information for drug-metabolising enzymes and transporters, and provides access to available quantitative information on drug exposure contained in the literature. It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites. This review gives a brief description of the database organisation, its search functionalities and examples of use.
Highlights
Differences in drug response among patients are common, often leading to challenges in optimising a dosage regimen for an individual patient
Genetic factors have long been known to cause interindividual differences in the pharmacokinetics, efficacy and adverse events of a number of drugs,[1] and drug metabolising enzymes have been shown to be the greatest source of pharmacogenetic (PGx) variability identified to date
It is estimated that over half of the 170 genes with products affecting drug disposition are polymorphic,[2] and clinically important polymorphisms have been identified for most major enzymes involved in both phase I and phase II drug metabolism.[3]
Summary
Differences in drug response among patients are common, often leading to challenges in optimising a dosage regimen for an individual patient. E-PKGene (www.pharmacogeneticsinfo.org) is a manually curated knowledge-based product which facilitates easy access to, and search for, quantitative information contained in the PGx literature base. It provides in-depth analysis of the impact of genetic variants of metabolising enzymes and transporters on pharmacokinetics. E-PKGene is designed directly to support drug development or Phase 1 translational research (T1) This tool has the capacity to support other phases of translational research, including Phase 2 (T2) evidence-based evaluations, which can better predict patient responses by providing clinical recommendations. Details about e-PKGene design and content, examples of use and types of support provided to various types of users are described
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