Abstract
The Metabolism and Transport Drug Interaction Database (http://www.druginteractioninfo.org) is a web-based research and analysis tool developed in the Department of Pharmaceutics at the University of Washington. The database has the largest manually curated collection of data related to drug interactions in humans. The tool integrates information from the literature, public repositories, reference textbooks, guideline documents, product prescribing labels and clinical review sections of new drug approval (NDA) packages. The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information. The database helps scientists to mine kinetics information for drug-metabolising enzymes and transporters, to assess the extent of in vivo drug interaction studies, as well as case reports for drugs, therapeutic proteins, food products and herbal derivatives. This review provides a brief description of the database organisation, its search functionalities and examples of use.
Highlights
Adverse drug reactions (ADRs) remain one of the leading causes of morbidity and mortality in healthcare
It is estimated that drug– drug interactions (DDIs) represent 3–5 per cent of all in-hospital medication errors and that they are an important cause of patient visits to emergency departments.[2]
While healthcare providers have been offered access to and have benefitted from numerous drug information tools that have provided them with guidance on how drugs can be co-administered, researchers within the drug development community have had access to a more limited portfolio of data repositories. These scientists need to browse the vast literature for primary scientific data that will provide them with context for their research findings and help with their drug interaction programme
Summary
Adverse drug reactions (ADRs) remain one of the leading causes of morbidity and mortality in healthcare. While healthcare providers have been offered access to and have benefitted from numerous drug information tools that have provided them with guidance on how drugs can be co-administered, researchers within the drug development community have had access to a more limited portfolio of data repositories These scientists need to browse the vast literature for primary scientific data (ie datasets on metabolic isozymes, transporters, substrates, inducers, and inhibitors) that will provide them with context for their research findings and help with their drug interaction programme. The database contains in vitro and in vivo kinetics information for drug-metabolising enzymes and transporters, pharmacokinetics parameters/pharmacodynamic measures and side effects reported in clinical drug interaction studies Each dataset integrates both the experimental design and the primary results. The database is widely used in clinical programmes, including the management of drug interactions of new drugs in multicentre trials.[4]
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