脳卒中発作後の血清ビタミンE, 過酸化脂質, 総コレステロール, 遊離脂肪酸に対するビタミンE投与の影響

Abstract

Serum levels of α-tocopherol, lipoperoxide (TBARS), total cholesterol (TC) and free fatty acid (FFA) were studied before and after the administration of vitamin E (dl-α-tocopheryl acetate) for 4 weeks (400mg/d im for the first week, thereafter 600mg/d po) in the acute stage of cerebrovascular accident (stroke).Serum α-tocopherol was significantly lower, but TBARS was higher than that of the control on the first day of outbreak. Then, vitamin E administration elevated serum α-tocopherol level in a few days, but did not affect on TC level. On the other hand, serum TBARS level did not arise and was in plateau during 4 weeks. These result led us to have a conclusion that administrated vitamin E must inhibit the elevation of TBARS, which otherwise, was observed in most cases in the first week. Lastly, there were three stroke patients whose serum α-tocopherol had been happenly measured 2 or 4 months prior to attack, and two of them had revealed low level of α-tocopherol (less than 0.5mg/dl) at that time. Soon after stroke developing, seum α-tocopherol was commonly proven to be lower, as others, in three patients.These findings might roughly suggest that low level of serum α-tocopherol could be one of risk factors of cerebrovascular accident.