Abstract
In the title compound, C19H18N2O3S, the thiazolidine ring makes dihedral angles of 46.97 (8) and 7.19 (9)° with the pyridine and benzene rings, respectively. The intramolecular structure is stabilized by a weak C—H...S hydrogen bond, which generates a S(6) graph-set motif, and a weak C—H...O contact. In the crystal, N—H...N and C—H...O hydrogen bonds leads to infinite one-dimensional chains along (201) and generate an R 2 2(7) ring-set motif. The crystal structure is further consolidated by weak π–π [centroid-to-centroid distance = 3.8204 (10) Å] interactions.
Highlights
In the title compound, C19H18N2O3S, the thiazolidine ring makes dihedral angles of 46.97 (8) and 7.19 (9) with the pyridine and benzene rings, respectively
The intramolecular structure is stabilized by a weak C—HÁ Á ÁS hydrogen bond, which generates a S(6) graph-set motif, and a weak C—HÁ Á ÁO contact
The intramolecular structure is stabilized by a weak C—HÁ Á ÁS hydrogen bond, which generates an S(6) graph-set motif (Fig. 1) and a weak C—HÁ Á ÁO contact (Table 1)
Summary
Thiazolidinediones are known to sensitize tissues to insulin have been developed and clinically used as antidiabetic agents. They have been shown to reduce plasma glucose and lipid levels and are used for the treatment of type 2 diabetes (Day, 1999; Spiegelman, 1998). In view of this biological importance, the crystal structure of the title compound (Fig. 1) been determined and the results are presented here.
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