Abstract
BackgroundOsteoarthritis (OA) is a multifactorial joint degenerative disease with low-grade inflammation. The gut microbiome has recently emerged as an pathogenic factor of OA, and prebiotics supplementation could alleviate OA symptoms in animal models. However, the relationship between the gut microbiome and OA in the older female adults is hitherto not clear.ResultsHere we studied the gut microbiome of 57 OA patients and their healthy controls by metagenome-wide association study based on previously published data. A significant reduction in the richness and diversity of gut microbiome were observed in OA patients. Bifidobacterium longum and Faecalibacterium prausnitzii were decreased while Clostridium spp. was increased in the OA group. The functional modules, particularly the energetic metabolism and acetate production were also decreased in the OA patients. To evaluate the diagnostic value of identified species for elderly patients with OA, we constructed a set of random forest disease classifiers based on species differences between the two groups. Among them, 9 species reached the lowest classification error in the random forest cross validation, and the area under ROC of the model was 0.81.ConclusionsSignificant alterations in the gut microbial composition and function were observed between the older patients with OA and their controls, and a random forest classifier model for OA were constructed based on the differences in our study. Our study have identified several potential gut microbial targets in the elderly females with OA, which will facilitate the treatment of OA based on gut microbiota, is of great value in alleviating pain and improving the quality of life for them.
Highlights
Osteoarthritis (OA) is a multifactorial joint degenerative disease with low-grade inflammation
To further study the metabolic disorders in non-obese mice and the role of the gut microbiome, Guss et al [16] applied the Toll-like receptor-5 deficient mice and found that alone it was not sufficient to induce OA, they suggested that increased levels of LPS in High fat diet (HFD)-fed mice was associated with higher Osteoarthritis cartilage histopathology assessment system (OARSI) scores and a dysbiosis of Firmicutes increase, which further clarified the gut microbial composition in OA occurrence and development
It’s worth noting that we used p < 0.05 as the significance criteria for different species and gut metabolic module (GMM) between the OA patients and their healthy controls since there was no significant difference between the two groups
Summary
Osteoarthritis (OA) is a multifactorial joint degenerative disease with low-grade inflammation. To further study the metabolic disorders in non-obese mice and the role of the gut microbiome, Guss et al [16] applied the Toll-like receptor-5 deficient mice and found that alone it was not sufficient to induce OA, they suggested that increased levels of LPS in HFD-fed mice was associated with higher OARSI scores and a dysbiosis of Firmicutes increase, which further clarified the gut microbial composition in OA occurrence and development. Consistent with Schott et al findings, Rios et al [18] showed that a maximum protection could be achieved by combining the oligofructose supplementation with exercise in HFD-fed rats with OA, with an increase in Bifidobacterium and Roseburia and a decrease in Clostridium leptum and Akkermansia muciniphila levels Another recent study in a guinea pig model of OA showed that oral administration of Bifidobacterium longum CBi0703 could reduce cartilage structural lesions and provide an overall joint protective effect [19]
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